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At the time of fertilization, when a spermatozoon encounters an oocyte, it very first binds to its membrane then, each membranes fuse with each other. Drastic oocyte membrane reorganization occurs (for overview [1]). Concerning the proteins of the oocyte membrane clearly involved in the process of gametes adhesion/fusion, one would be the tetraspanin Cd9 [2,three,4], the other is, at the least, one but still unknown, glycosylphosphatidylinositol-anchored protein (GPIanchored protein) [5,6]. We have currently hypothesized on the links amongst these two proteins and in specific around the membrane reorganization in the time of g.